کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3428400 1594365 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication
چکیده انگلیسی


• Endosomal trafficking pathways play an important role in HIV-1 replication.
• Silencing components of the COG complex impairs early events in the viral life cycle.
• The COG-mediated impairment in HIV-1 infection is dependent on the HIV-1 envelope.

All viruses require host cell factors to replicate. A large number of host factors have been identified that participate at numerous points of the human immunodeficiency virus 1 (HIV-1) life cycle. Recent evidence supports a role for components of the trans-Golgi network (TGN) in mediating early steps in the HIV-1 life cycle. The conserved oligomeric Golgi (COG) complex is a heteroctamer complex that functions in coat protein complex I (COPI)-mediated intra-Golgi retrograde trafficking and plays an important role in the maintenance of Golgi structure and integrity as well as glycosylation enzyme homeostasis. The targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication. This inhibition of HIV-1 replication preceded late reverse transcription (RT) but did not affect viral fusion. Silencing of the COG interacting protein the t-SNARE syntaxin 5, showed a similar defect in late RT product formation, strengthening the role of the TGN in HIV replication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 192, 4 November 2014, Pages 92–102
نویسندگان
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