کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3429527 1228251 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths
چکیده انگلیسی

Core protein of hepatitis B virus (HBV) with various C-terminal lengths (residue 154, 164, 167 and 183) can self-assemble into recombinant hepatitis B core antigen (HBcAg) particles. To understand the RNA encapsidation mechanism of HBV, the three-dimensional structures of these particles were reconstructed by cryo-electron microscopy (cryoEM). Detailed structural comparisons showed that their capsid structures are highly similar, while the RNA content is increased upon the retention of more amino acid residues at the C-terminus of core protein, suggesting the crucial role of the basic C-terminal tail on determining the genome size.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 149, Issue 2, May 2010, Pages 241–244
نویسندگان
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