کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3429684 1594395 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Myxoma virus M130R is a novel virulence factor required for lethal myxomatosis in rabbits
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Myxoma virus M130R is a novel virulence factor required for lethal myxomatosis in rabbits
چکیده انگلیسی
Myxoma virus (MV) is a highly lethal, rabbit-specific poxvirus that induces a disease called myxomatosis in European rabbits. In an effort to understand the function of predicted immunomodulatory genes we have deleted various viral genes from MV and tested the ability of these knockout viruses to induce lethal myxomatosis. MV encodes a unique 15 kD cytoplasmic protein (M130R) that is expressed late (12 h post infection) during infection. M130R is a non-essential gene for MV replication in rabbit, monkey or human cell lines. Construction of a targeted gene knockout virus (vMyx130KO) and infection of susceptible rabbits demonstrate that the M130R knockout virus is attenuated and that loss of M130R expression allows the rabbit host immune system to effectively respond to and control the lethal effects of MV. M130R expression is a bona fide poxviral virulence factor necessary for full and lethal development of myxomatosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 144, Issues 1–2, September 2009, Pages 258-265
نویسندگان
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