کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3430553 | 1228277 | 2008 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Animal models and vaccines for SARS-CoV infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Animal models and vaccines for SARS-CoV infection Animal models and vaccines for SARS-CoV infection](/preview/png/3430553.png)
چکیده انگلیسی
We summarize findings of SARS-CoV infections in several animal models each of which support viral replication in lungs accompanied by histopathological changes and/or clinical signs of illness to varying degrees. New findings are reported on SARS-CoV replication and associated pathology in two additional strains (C57BL/6 and 129S6) of aged mice. We also provide new comparative data on viral replication and associated pathology following infection of golden Syrian hamsters with various SARS-CoV strains and report the levels of neutralizing antibody titers following these infections and the cross-protective efficacy of infection with these strains in protecting against heterologous challenge. Finally, we summarize findings of a variety of vaccine approaches and discuss the available in vitro and in vivo data addressing the potential for disease enhancement following re-infection in animals previously vaccinated against or infected with SARS-CoV.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 133, Issue 1, April 2008, Pages 20-32
Journal: Virus Research - Volume 133, Issue 1, April 2008, Pages 20-32
نویسندگان
Anjeanette Roberts, Elaine W. Lamirande, Leatrice Vogel, Jadon P. Jackson, Christopher D. Paddock, Jeannette Guarner, Sherif R. Zaki, Timothy Sheahan, Ralph Baric, Kanta Subbarao,