کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3430890 1594404 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effective replication of human influenza viruses in mice lacking a major α2,6 sialyltransferase
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Effective replication of human influenza viruses in mice lacking a major α2,6 sialyltransferase
چکیده انگلیسی

The hemagglutinins of influenza viruses isolated from humans typically prefer binding to sialic acid in an α2,6 linkage. Presumably, the virus uses the presence of these receptors on the respiratory tract to gain entrance into the host cell. The ST6Gal I sialyltransferase knock-out mouse lacks the main enzyme necessary for the attachment of α2,6 sialic acid to N-linked glycoproteins on the cell surface. Yet even in the absence of detectable α2,6 sialic acid in the mouse respiratory tract, human influenza viruses can still infect these mice and grow to similar titers in the lung and trachea as compared to wild-type animals. This work demonstrates that the presence of a major α2,6 sialic acid on N-linked glycoproteins is not essential for human influenza virus infection in mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 126, Issues 1–2, June 2007, Pages 9–18
نویسندگان
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