کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3431412 1228305 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The amino-terminal residue of glycoprotein B is critical for neutralization of bovine herpesvirus 1
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
The amino-terminal residue of glycoprotein B is critical for neutralization of bovine herpesvirus 1
چکیده انگلیسی
In order to address the neutralization epitope on bovine herpesvirus 1 (BHV1) glycoprotein B (gB), a panel of monoclonal antibodies (MAbs), a series of truncation forms of the glycoprotein and an MAb-escape mutant were used in this study. Immunocytochemistry on the truncations using MAbs against the glycoprotein revealed that the neutralization epitopes recognized by the MAbs lay between residues 1 and 52 of mature gB. Comparison of the sequences among the mutant, parent, and revertant viruses demonstrated that the amino-terminal residue of mature gB of the escape mutant was changed from Arg to Gln. These findings indicate that the amino-terminal residue of gB is critical for neutralization of BHV1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 115, Issue 2, February 2006, Pages 105-111
نویسندگان
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