Avian influenza vaccines against H5N1 ‘bird flu’

• We review the development and application of inactivated vaccines.
• We review the development and application of recombinant virus vector vaccines.
• Recombinant duck enteritis virus (DEV) vector vaccine shows superior efficacy in ducks and broilers.
• A DNA vaccine is effective and close to being used for H5N1 avian influenza (AI).

H5N1 avian influenza viruses (AIVs) have spread widely to more than 60 countries spanning three continents. To control the disease, vaccination of poultry is implemented in many of the affected countries, especially in those where H5N1 viruses have become enzootic in poultry and wild birds. Recently, considerable progress has been made toward the development of novel avian influenza (AI) vaccines, especially recombinant virus vector vaccines and DNA vaccines. Here, we will discuss the recent advances in vaccine development and use against H5N1 AIV in poultry. Understanding the properties of the available, novel vaccines will allow for the establishment of rational vaccination protocols, which in turn will help the effective control and prevention of H5N1 AI.