کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
37203 45322 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computational tools for modeling xenometabolism of the human gut microbiota
ترجمه فارسی عنوان
ابزار محاسباتی برای مدل سازی زنجبیل مزانشیمی میکروب بیوتین روده
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی


• We provide a conceptual overview of the hierarchy of xenometabolic processes in the gut microbiota.
• We review computational tools relevant for modeling complex xenometabolic processes.
• We present a unified perspective towards building holistic models of xenometabolism.

The gut microbiota is increasingly being recognized as a key site of metabolism for drugs and other xenobiotic compounds that are relevant to human health. The molecular complexity of the gut microbiota revealed by recent metagenomics studies has highlighted the need as well as the challenges for system-level modeling of xenobiotic metabolism in the gut. Here, we outline the possible pathways through which the gut microbiota can modify xenobiotics and review the available computational tools towards modeling complex xenometabolic processes. We put these diverse computational tools and relevant experimental findings into a unified perspective towards building holistic models of xenobiotic metabolism in the gut.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 32, Issue 3, March 2014, Pages 157–165
نویسندگان
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