کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3817071 | 1246302 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Porphyrins in urine after administration of 5-aminolevulinic acid as a potential tumor marker Porphyrins in urine after administration of 5-aminolevulinic acid as a potential tumor marker](/preview/png/3817071.png)
SummaryBackgroundTumor markers are commonly used for cancer screening and as indicators of therapeutic effects. Certain types of tumor have been known to produce a variety of porphyrins after 5-aminolevulinic acid (ALA) administration. In this study, porphyrins in tumor-bearing mouse urine were analyzed after oral administration of ALA in order to identify new tumor markers excreted in the urine.MethodsPorphyrin concentrations in the urine of tumor-bearing mice were measured after administration of 1.0 mg of ALA (approximately 50 mg kg−1).ResultsPorphyrin concentrations in the urine of tumor-bearing mice increased after administration of ALA. HPLC analysis of the urine revealed the existence of uroporphyrin (UP) and coproporphyrin (CP) in the urine of ALA-treated tumor-bearing mice. Furthermore, at 3 h after ALA administration, UP concentrations in the urine of tumor-bearing mice significantly increased compared to those in the urine of normal mice.ConclusionThese results suggest that UP as a precursor of heme detected in the urine of tumor-bearing mice after ALA administration is a potential marker of tumor development.
Journal: Photodiagnosis and Photodynamic Therapy - Volume 8, Issue 4, December 2011, Pages 328–331