کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3817508 1246328 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical study of Photofrin photodynamic therapy for the treatment of relapse nasopharyngeal carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Clinical study of Photofrin photodynamic therapy for the treatment of relapse nasopharyngeal carcinoma
چکیده انگلیسی

SummaryObjectivesTo evaluate the clinical response and adverse effects of Photofrin photodynamic therapy (PDT) in patients with relapse nasal pharyngeal cancer.MethodsThirty patients with relapse nasal pharyngeal cancer were randomly divided into PDT group and chemotherapy group. In PDT group, patients received intravenous administration of Photofrin (2 mg/kg b.w.) and 48 h later light (200–300 J/cm) was delivered by a 630 nm diode laser through a cylinder diffuser under endoscopic assistance. Two days after PDT the necrotic tissues were removed and newly identified sites were subject to another round of light irradiation. In chemotherapy group, the routine cisplatin and 5-fluorouracil (DDP/5-FU) remedy was used. Endoscopic and radiological examinations were performed during 6 months follow-up. The Karnofsy Score was used to evaluate the quality of life.ResultsThe local response and nasal cavity obstruction remission rate in PDT group were better than that in chemotherapy group. The Karnofsy Score was also improved in PDT group.ConclusionThis pilot study suggests that Photofrin PDT is effective and safe in treatment of advanced nasal pharyngeal cancer and management of nasal obstruction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Photodiagnosis and Photodynamic Therapy - Volume 3, Issue 4, December 2006, Pages 266–271
نویسندگان
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