کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3841156 1247962 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prevention of allograft rejection by amplification of Foxp3+CD4+CD25+ regulatory T cells
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Prevention of allograft rejection by amplification of Foxp3+CD4+CD25+ regulatory T cells
چکیده انگلیسی

CD4+CD25+ T cells were identified originally as potent suppressors of autoimmunity and were later termed “natural regulatory T cells” or nTreg cells. Subsequently, a transcription factor called forkhead box protein 3 (Foxp3) was identified to be a critical regulator for Treg differentiation and function. Foxp3+CD4+CD25+ Treg cells have been increasingly documented to suppress allograft rejection and to mediate allograft tolerance in transplantation. In this article, the authors review current approaches for amplification of allo-specific Foxp3+CD4+CD25+ Treg cells for prevention of allograft rejection and induction of allo-specific transplant tolerance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 153, Issue 2, February 2009, Pages 60–70
نویسندگان
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