کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3841563 | 1247987 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Desferri-Exochelin, a lipid-soluble, hexadentate iron chelator, effectively removes tissue iron
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کلمات کلیدی
i.p.dpmFDAH&E - H & Eanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancedisintegrations per minute - تخریب در دقیقهstandard error - خطای استانداردIntraperitoneally - داخل صفاقیIntravenous - داخل وریدیFood and Drug Administration - سازمان غذا و داروHematoxylin and Eosin - هماتوکسیلین و ائوزین
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Desferri-Exochelin, a lipid-soluble, hexadentate iron chelator, effectively removes tissue iron Desferri-Exochelin, a lipid-soluble, hexadentate iron chelator, effectively removes tissue iron](/preview/png/3841563.png)
چکیده انگلیسی
Chronic iron-overload is damaging to the heart, liver, and other organs. Better iron chelators are needed to treat this serious medical condition. The uptake and distribution of the lipid-soluble, hexadentate iron chelator desferri-Exochelin 772SM (D-Exo) is studied and its efficacy in removing iron from tissue in rodent models is evaluated. After an intravenous bolus of tritiated D-Exo to rats, counts rapidly disappeared from the blood and rapidly appeared in 15 organs studied, usually peaking within 15 min. There was considerable uptake in the heart and liver, 2 organs especially susceptible to damage from clinical iron overload. To assess actual decreases in cardiac and hepatic iron in response to D-Exo, mice loaded with 42 mg of iron dextran (2100 mg/kg) were studied. Untreated, iron-loaded mice sacrificed 9 weeks later had a 4-fold increase in cardiac iron and a 20-fold increase in hepatic iron compared with controls that were not iron-loaded. In iron-loaded mice treated with 7 mg of D-Exo intraperitoneally (i.p.) 4 days/week for 8 weeks (total 224 mg), tissue iron, measured by atomic absorption, was reduced by 20% in the liver and 25% in the heart (P < 0.01 for each organ). During the first 8 h after a D-Exo dose, iron was excreted in the urine. Mice treated with D-Exo gained weight normally and showed no evidence of toxicity. In conclusion, in this iron-overload mouse model, D-Exo administered intravenously or i.p. rapidly diffuses into multiple organs, including the heart and liver, and effectively removes iron without apparent toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 148, Issue 2, August 2006, Pages 63-71
Journal: Translational Research - Volume 148, Issue 2, August 2006, Pages 63-71
نویسندگان
Yvonne K. Hodges, Howard D. Weinberger, Janet Stephens, Marcus A. Horwitz, Lawrence D. Horwitz,