کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3910013 | 1251240 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status
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کلمات کلیدی
α-MEMFBSMPATFRHRT17β-estradiol - 17β استرادیولIron - آهنEstrogen - استروژنTAM - تامtamoxifen - تاموکسیفنCell proliferation - تکثیر سلولیBreast cancer - سرطان پستانfetal bovine serum - سرم جنین گاوhormone replacement therapy - هورمون جایگزین درمانProgesterone - پروژسترونEstrogen receptor - گیرنده استروژنtransferrin receptor - گیرنده انتقالینProgesterone receptor - گیرنده پروژسترونMenopause - یائسگی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
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چکیده انگلیسی
Estrogen and iron play critical roles in a female body development and were investigated in the present study in relation to in vitro cell proliferation. Premproâ¢, a hormone replacement therapy drug, and 17β-estradiol (E2) were shown to increase cell proliferations in estrogen receptor positive (ER+) cells independent of progesterone receptor (PR) status. For example, increased cell proliferation was observed in ER+/PR+ human breast cancer MCF-7, its matching non-cancerous human breast epithelial MCF-12A, and ER+/PR+ murine mammary cancer MXT+ cells, but not in ERâ/PRâ MDA-MB-231, its matching non-cancerous MCF-10A, and MXTâ (ERâ/PR+) cells. By mimicking post-menopausal conditions of high estrogen in local breast tissue and increased iron levels due to cessation of menstrual periods, E2 and iron were shown to exert synergistic effects on proliferation of MCF-7 cells and significantly increased Ki67 and proliferating cell nuclear antigen. Western blotting of E2-treated ER+ but not ERâ cells showed that E2 also increased transferrin receptor (TfR). Further studies are needed to assess the mitogenic effects of iron and estrogen in normal post-menopausal breast.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 17, Issue 2, April 2008, Pages 172-179
Journal: The Breast - Volume 17, Issue 2, April 2008, Pages 172-179
نویسندگان
Jisen Dai, Jinlong Jian, Maarten Bosland, Krystyna Frenkel, Güenther Bernhardt, Xi Huang,