کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
396222 666309 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A hierarchical refinement algorithm for fully automatic gridding in spotted DNA microarray image processing
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر هوش مصنوعی
پیش نمایش صفحه اول مقاله
A hierarchical refinement algorithm for fully automatic gridding in spotted DNA microarray image processing
چکیده انگلیسی

Gridding, the first step in spotted DNA microarray image processing, usually requires human intervention to achieve acceptable accuracy. We present a new algorithm for automatic gridding based on hierarchical refinement to improve the efficiency, robustness and reproducibility of microarray data analysis. This algorithm employs morphological reconstruction along with global and local rotation detection, non-parametric optimal thresholding and local fine-tuning without any human intervention. Using synthetic data and real microarray images of different sizes and with different degrees of rotation of subarrays, we demonstrate that this algorithm can detect and compensate for alignment and rotation problems to obtain reliable and robust results.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Information Sciences - Volume 177, Issue 4, 15 February 2007, Pages 1123–1135
نویسندگان
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