کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3979405 | 1257332 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Voie de signalisation Sonic Hedgehog : du développement embryonnaire aux thérapies moléculaires ciblées
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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![عکس صفحه اول مقاله: Voie de signalisation Sonic Hedgehog : du développement embryonnaire aux thérapies moléculaires ciblées Voie de signalisation Sonic Hedgehog : du développement embryonnaire aux thérapies moléculaires ciblées](/preview/png/3979405.png)
چکیده انگلیسی
It has long been known that the hedgehog signaling pathway is crucial for embryonic development, in both Drosophila and vertebrate systems. During the past few years its implication in carcinogenesis has become clear and today it is acknowledged that this pathway plays a role in the malignant transformation of multiple cell types, either owing to the mutation of some of its components or to its erratic activation. New molecular targeted therapies that inhibit the pathway have shown their unquestionable efficiency in several tumours -among which basal cell carcinoma, medulloblastoma, or pancreatic adenocarcinoma. The assessment of these inhibitors in other types of tumours is currently underway with promising results, suggesting that the Sonic hedgehog signalling pathway may become one of the therapeutic targets of the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 97, Issue 12, December 2010, Pages 1477-1483
Journal: Bulletin du Cancer - Volume 97, Issue 12, December 2010, Pages 1477-1483
نویسندگان
Watson S., Serrate C., Vignot S.,