کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3979417 1257333 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rôle de la transition épithéliomésenchymateuse dans la progression tumorale
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Rôle de la transition épithéliomésenchymateuse dans la progression tumorale
چکیده انگلیسی
The epithelial-mesenchymal transition (EMT) is a morphogenetic program that converts epithelial into mesenchymal cells during the embryonic development. This mechanism is frequently reactivated during tumor progression and provides cells with motility and invasive capabilities favoring the metastatic dissemination from epithelial tumors. Various EMT-inducing transcription factors, such as the TWIST proteins, were also shown to inhibit oncogene-induced failsafe programs (senescence and apoptosis), thereby promoting the progression from benign to malignant stages. Altogether, these observations suggest that EMT could play an important role in favoring both tumor development and metastatic dissemination.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 97, Issue 1, January 2010, Pages 7-15
نویسندگان
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