کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3979763 1601110 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Do platinum salts fit all triple negative breast cancers?
ترجمه فارسی عنوان
آیا نمکهای پلاتین مناسب همه سرطانهای سه گانه منفی پستان هستند؟
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی


• The phenotype of BRCA wild-type TNBC often resembles the one of BRCA-related cancer.
• BRCAness can be caused by epigenetic alterations or a RAD51 complex impairment.
• Rearrangements analysis by high-throughput technologies predict response to platinum.
• In neoadjuvant setting adding carboplatin improves pCR rates selectively in TNBC.
• First-line carboplatin improves response rate only in BRCA1/2-mutated TNBC.

Triple-negative breast cancer (TNBC) is an aggressive disease with limited treatment options and poor prognosis once metastatic. Pre-clinical and clinical data suggest that TNBC could be more sensitive to platinum-based chemotherapy, especially among BRCA1/2-mutated patients. In recent years, several randomised trials have been conducted to evaluate platinum efficacy in both early-stage and advanced TNBC, with conflicting results especially for long-term outcomes. Experimental studies are now focusing on identifying biomarkers of response to help selecting patients who may benefit most from platinum-based therapies, including BRCA1/2 mutational status and genomic instability signatures (such as HRD-LOH or HRD-LST scores). A standard therapy for TNBC is still missing and platinum-based regimens represent an emerging therapeutic option for selected patients with a defect in the homologous recombination repair system. The identification of these patients through validated biomarker assays will be crucial to optimize the use of currently approved agents in TNBC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 48, July 2016, Pages 34–41
نویسندگان
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