کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3979860 1257384 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetic targeting in pancreatic cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Epigenetic targeting in pancreatic cancer
چکیده انگلیسی

The prognosis of pancreatic cancer patients is very poor, with a 5-year survival of less than 6%. Therefore, there is an urgent need for new therapeutic options in pancreatic cancer. In the past years it became evident that deregulation of epigenetic mechanisms plays an important role in pancreatic carcinogenesis. This review focuses on the exploitation of drugs that alter histone modifications, DNA methylation and microRNA expression as options for the treatment of pancreatic cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 40, Issue 5, June 2014, Pages 656–664
نویسندگان
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