کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3979909 1257391 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Osteosarcoma treatment – Where do we stand? A state of the art review
ترجمه فارسی عنوان
پوکی استخوان ما کجا ایستاده ایم؟ یک وضعیت از نظر هنر
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

Long-term outcome for patients with high-grade osteosarcoma has improved with the addition of systemic chemotherapy, but subsequent progress has been less marked. Modern, multiagent, dose-intensive chemotherapy in conjunction with surgery achieves a 5-year event-free survival of 60–70% in extremity localized, non-metastatic disease. A major, as yet unsolved, problem is the poor prognosis for metastatic relapse or recurrence, and for patients with axial disease. This article reviews the current state of the art of systemic osteosarcoma therapy by focusing on the experiences of cooperative osteosarcoma groups. Also, we shed light on questions and challenges posed by the aggressiveness of the tumor, and we consider potential future directions that may be critical to progress in the prognosis of high-grade osteosarcoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 40, Issue 4, May 2014, Pages 523–532
نویسندگان
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