کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3980067 1257403 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecularly targeted therapies in unresectable-metastatic gastric cancer. A systematic review
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Molecularly targeted therapies in unresectable-metastatic gastric cancer. A systematic review
چکیده انگلیسی

SummaryGastric cancer is the second leading cause of cancer related-death. Most patients present with an advanced stage of disease that has a dismal outcome. Evidently, there is a clear need for the development of new agents with novel mechanisms of action in the treatment of this disease. A number of biological agents modulating different signal transduction pathways are currently in clinical development, such as angiogenesis inhibitors and agents targeting epidermal growth factor receptor, cell cycle, matrix metalloproteinases, cyclooxygenase-2 (COX-2), mammalian target of rapamycin (mTOR) or proteasome. This is the first systematic review of the literature to synthesize all available data coming from trials and evaluate the efficacy and safety of molecular targeted drugs in unresectable and metastatic gastric cancer. As knowledge accumulates on the molecular mechanisms underlying carcinogenesis in the stomach, the anticipated development and assessment of molecularly targeted agents may offer a promising perspective for a disease which, to date, remains incurable.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 37, Issue 8, December 2011, Pages 599–610
نویسندگان
, , , ,