کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3980204 1257417 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: Current status and future directions
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: Current status and future directions
چکیده انگلیسی

SummaryAberrant activation of HER2 through overexpression has been shown to play an important role in some breast cancers. Therapies against this receptor including the monoclonal antibody, trastuzumab, or the small tyrosine kinase inhibitor, lapatinib have shown to improve the prognosis of such patients. Despite overexpressing HER2, some patients do not respond to these targeted treatments or progress after a short period of time. Irreversible tyrosine kinase inhibitors have been developed to bypass several pathways that could be involved in this resistance. In vitro, these agents have been shown to be more potent and to prolong target inhibition. Clinical development of these agents is ongoing and early results are promising. This review will describe the biologic rationale that justifies the development of these agents in breast cancer focusing on the current status and future directions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 35, Issue 8, December 2009, Pages 685–691
نویسندگان
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