کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3980609 | 1257442 | 2008 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exploring the role of novel agents in the treatment of renal cell carcinoma
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
SummaryRenal cell carcinoma represents nearly 3% of all cancers, predominantly affecting individuals ⩾50 years of age, and until recently, few treatments options were available for metastatic disease. The 5-year median survival for these patients with metastatic renal cell carcinoma has been estimated at <10%. This review explores the data of the most relevant trials focusing on new approaches with novel agents, including sunitinib, sorafenib, bevacizumab, temsirolimus, as well as their combinations with traditional agents. We describe mechanisms of action, activity, and toxicity profile of those agents, as well as administration schedules that have been studied in clinical trials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 34, Issue 8, December 2008, Pages 750–760
Journal: Cancer Treatment Reviews - Volume 34, Issue 8, December 2008, Pages 750–760
نویسندگان
Fernando Cotait Maluf, Gustavo dos Santos Fernandes, Ariel Galapo Kann, José Luis Aguilar-Ponce, Jaime de la Garza, Antonio Carlos Buzaid,