کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3984753 1601375 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Time to local recurrence as a prognostic factor in patients with rectal cancer
ترجمه فارسی عنوان
زمان عود مجدد به عنوان یک عامل پیش آگهی در بیماران مبتلا به سرطان رکتوم
کلمات کلیدی
سرطان رکتوم عود محلی زمان به عود مجدد بقا، عوامل پیش آگهی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

AimsSurvival after the local recurrence of rectal cancer is influenced by several factors. The aim of this study was to ascertain whether the time interval from primary surgery for rectal cancer to local recurrence diagnosis has any impact on survival.MethodsPopulation-based data was collected from the Swedish Colorectal Cancer Registry. 7410 patients were operated with radical abdominal surgery for rectal cancer during the period 1995–2002. Of these, 386 (5%) developed a local recurrence as a first event. The patients were divided into two groups: early local recurrence (ELR), diagnosed <12 months after primary surgery, and late local recurrence (LLR), diagnosed ≥12 months after primary surgery. Kaplan–Meier curves and hazard ratios were calculated for survival analyses. Survival was calculated from the date of the local recurrence diagnosis to death or end of follow-up.ResultsNinety-five patients had ELR and 291 patients LLR. Median time to local recurrence was 1.7 (0.1–7.9) years. Patients with a stage III primary tumour and non-irradiated patients were more common in the ELR compared with the LLR group. Factors that influenced survival were age at diagnosis of local recurrence (p < 0.001), stage of primary tumour (p = 0.027), and surgical resection of local recurrence (p < 0.001). Time to diagnosis of local recurrence had no influence on survival.ConclusionsNo difference in survival from date of diagnosis of local recurrence was seen between patients with ELR and patients with LLR. All patients with local recurrence should therefore be assessed for potential curative surgery, disregarding time to local recurrence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 41, Issue 5, May 2015, Pages 659–666
نویسندگان
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