کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3986490 | 1601407 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Elderly and very elderly advanced ovarian cancer patients: Does the age influence the surgical management? Elderly and very elderly advanced ovarian cancer patients: Does the age influence the surgical management?](/preview/png/3986490.png)
BackgroundTo examine the surgical treatment and clinical outcome of elderly and very elderly advanced epithelial ovarian cancer patients.MethodsWe retrospectively analyzed FIGO stage IIIC–IV ovarian cancer patients, divided in elderly (Group A, >65 and <75 years) and very elderly patients (Group B, ≥75 years) treated by primary debulking surgery (PDS) or by interval debulking surgery (IDS) at the Catholic University at Rome and Campobasso, Italy.Results164 patients were included: 123 (Group A) and 41 (Group B). Complete cytoreduction was achieved in 60 patients (60.6%) in Group A and in 20 patients (62.5%) in Group B (p = 0.75). In the remaining cases, optimal cytoreduction was performed (39 cases (39.4%) in Group A and 12 (37.5%) in Group B; p = 0.75). In Group A complete/optimal debulking was achieved in 53 patients (53.5%) at PDS and in 46 patients (46.5%) at IDS (p = 0.55). In the Group B a higher rate of patients was debulked at IDS with respect to PDS (10 (31.3%) vs. 22 patients (68.7%); p = 0.02). In Group A patients debulked at PDS showed better DFS (p = 0.007) and OS (p = 0.003) with respect to patients submitted to successful IDS, whereas in group B we did not observed any survival difference according to time of cytoreduction.ConclusionsOur data suggest that elderly and very elderly patients may tolerate radical and ultra-radical surgery. These patients should be managed in a gynecologic oncology unit, with prudent but complete approach.
Journal: European Journal of Surgical Oncology (EJSO) - Volume 38, Issue 12, December 2012, Pages 1204–1210