کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3986492 | 1601407 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Radioguided occult lesion localisation (ROLL) in breast-conserving surgery after neoadjuvant chemotherapy Radioguided occult lesion localisation (ROLL) in breast-conserving surgery after neoadjuvant chemotherapy](/preview/png/3986492.png)
BackgroundAn important benefit of neoadjuvant chemotherapy, as compared to adjuvant chemotherapy, in breast cancer patients is down staging of the primary tumour, which allows for more breast-conserving surgery. When a tumour becomes non-palpable after this down staging, precise localisation of the original tumour bed is crucial to be able to perform breast-conserving surgery. Radioguided Occult Lesion Localisation with 99mTechnetium (ROLL-99mTc) is commonly used to perform breast-conserving surgery in patients with non-palpable breast tumours. We modified this technique to use it in the neoadjuvant setting. The present analysis was performed to assess its feasibility and analyse the number of patients in which a mastectomy was correctly withheld using this technique.MethodsA retrospective analysis was performed for all patients who were treated with neoadjuvant chemotherapy between 2007 and 2010 in our institute and underwent breast-conserving surgery with the ROLL-99mTc technique afterwards. The status of the margins and the weight of the resected specimen were assessed.ResultsThe median weight of the resected specimen in these 83 patients was 53 g (range: 11–204 g). Eleven of the 58 patients with residual disease revealed positive margins at pathological examination. However, in only 5 of those 11 patients a secondary mastectomy was indicated. This means that in 94% of all included patients a mastectomy was correctly withheld.ConclusionThe ROLL-99mTc technique is a feasible technique that can be used to perform breast-conserving surgery after neoadjuvant chemotherapy in a carefully selected group of patients.
Journal: European Journal of Surgical Oncology (EJSO) - Volume 38, Issue 12, December 2012, Pages 1218–1224