کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3986898 | 1601426 | 2011 | 10 صفحه PDF | دانلود رایگان |

BackgroundThis systematic review examines whether radioguided localization surgery (RGL) (radioguided occult lesion localization – ROLL and radioguided seed localization – RSL) for non-palpable breast cancer lesions produces lower positive margin rates than standard wire-guided localization surgery.MethodsWe performed a comprehensive literature review to identify clinical studies using either ROLL or RSL. Included studies examined invasive or in situ BC and reported pathologically assessed margin status or specimen volume/weight. Two reviewers independently assessed study eligibility and quality and abstracted relevant data on patient and surgical outcomes. Quantitative data analyses were performed.ResultsFifty-two clinical studies on ROLL (n = 46) and RSL (n = 6) were identified. Twenty-seven met our inclusion criteria: 12 studies compared RGL to WGL and 15 studies were single cohorts using RGL. Ten studies were included in the quantitative analyses. Data for margin status and re-operation rates from 4 randomized controlled trials (RCT; n = 238) and 6 cohort studies were combined giving a combined odds ratio (OR) of 0.367 and 95% confidence interval (CI): 0.277 to 0.487 (p < 0.001) for margins status and OR 0.347, 95% CI: 0.250 to 0.481 (p < 0.001) for re-operation rates.ConclusionsThe results of this systematic review of RGL versus WGL demonstrate that RGL technique produces lower positive margins rates and fewer re-operations. While this review is limited by the small size and quality of RCTs, the odds ratios suggest that RGL may be a superior technique to guide surgical resection of non-palpable breast cancers. These results should be confirmed by larger, multi-centered RCTs.
► ROLL (radioguided occult lesion localization) and radioguided seed localization were reviewed.
► 4 RCTs and 6 non-randomized cohorts were included in quantitative analyses.
► Meta-analysis results for margin status and re-operation rates favoured radioguided surgery.
► Review limited by small sample sizes and low quality studies; larger, high quality RCT needed.
Journal: European Journal of Surgical Oncology (EJSO) - Volume 37, Issue 5, May 2011, Pages 388–397