کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3987648 1601468 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adjuvant cyclic Tamoxifen and Megestrol acetate treatment in postmenopausal breast cancer patients – Longterm follow-up
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Adjuvant cyclic Tamoxifen and Megestrol acetate treatment in postmenopausal breast cancer patients – Longterm follow-up
چکیده انگلیسی

AimsTo evaluate possible differences in effect on recurrence-free survival (RFS) and overall survival (OS) in node positive postmenopausal breast cancer patients receiving Tamoxifen or cyclic Tam and Megestrol acetate as adjuvant treatment.MethodsBetween 1989 and 1994, 489 patients with pT1–2pN+ hormone receptor positive or unknown tumours were included in a randomized national multicenter study to receive either Tam alone or cyclic Tam (8 weeks) and MA (8 weeks) for 2 years. Final follow-up was completed as of June 2002.Time from start of treatment to first recurrence and novel primary breast tumour, overall survival and cancer specific survival were estimated.ResultsNo differences in RFS, OS or cancer specific survival were observed between the two treatment groups.ConclusionsAdjuvant treatment used as standard Tam alone, compared to Tam and MA, as employed in this group of patients gave similar outcomes. Side effects that led to cessation of study medication were observed in both arms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 34, Issue 1, January 2008, Pages 6–12
نویسندگان
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