Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia

AimsTo characterize aspects of Nedd4L in prostate cancer (PC) by assessing its expression in hyperplastic and malignant prostate tissue, and to correlate findings with PC histologic grade.Materials and methodsRadical prostatectomy (RP) specimens from 56 patients with clinically localized PC, and benign prostatic hyperplasia (BPH) transurethral resection specimens from 31 patients, were assessed for Nedd4L expression using immunohistochemistry.ResultsNedd4L (P < 0.001) expressions were significantly decreased in PC compared to benign prostate tissue. Furthermore, downregulation of Nedd4L (P < 0.05) expression correlated with increasing Gleason score.ConclusionsThese data suggest that prostate cancer cells in vivo may need Nedd4L expression to regulate TGF-β1 signaling, and that Nedd4L expression might be involved in prostate cancer development.