کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3987937 1601471 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Incidence and prognostic influence of lymph node micrometastases in rectal cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Incidence and prognostic influence of lymph node micrometastases in rectal cancer
چکیده انگلیسی

AimsThe aim of this study was to determine the rate of lymph node micrometastases and evaluate their prognostic significance in rectal cancer.MethodsPatients with either Dukes A or B rectal carcinoma who had undergone curative resection by either low anterior resection or abdominal perineal resection between 1991 and 2000 were selected from a prospectively collated database. None of the patients had metastasis at the time of surgery and none received adjuvant or neoadjuvant therapy. A single section from each lymph node was stained with haematoxylin and eosin (H + E) and with CAM 5.2 by immunohistochemistry. Statistical analyses were performed with Chi-square test.ResultsA total of 774 lymph nodes with a median of 14 lymph nodes per patient were examined, from a cohort of 56 patients with a median age of 66 years. In the 56 patients in whom lymph node metastases were not detected by haematoxylin–eosin staining, cytokeratin staining was positive in 15 lymph nodes from 10 patients. Nine patients had disease recurrence at a median follow-up of 98 months. The presence of lymph node micrometastases by immunohistochemistry did not predict either disease-free (p = 0.44) or overall survival (p = 0.63).ConclusionImmunohistochemical staining detects micrometastases in rectal cancer which are not observed with H + E staining. However, no significant relationship was observed between disease relapse and rectal micrometastases detected by immunohistochemistry.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 33, Issue 8, October 2007, Pages 998–1002
نویسندگان
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