کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3987973 | 1601481 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Response to neoadjuvant chemotherapy and effects of tumor regression in gastric cancer Response to neoadjuvant chemotherapy and effects of tumor regression in gastric cancer](/preview/png/3987973.png)
AimsAim of this study is the evaluation of the effects induced by neoadjuvant chemotherapy (NACT) and its impact on survival on a series of locally advanced gastric carcinomas.MethodsDownstaging was assessed comparing pre-treatment clinical and laparoscopic staging with post-operative pathologic staging on 30 consecutive patients who completed a 3-year follow-up. Tumor downstaging and the grade of pathologic response were included in a statistical correlation between tumor regression induced by NACT and 3-year survival.ResultsIn this series tumor downstaging was obtained in 13 out of 30 patients. After the completion of 3-year follow-up, overall survival was >37.5 months with an overall survival rate of 56.7%; this figure reached up to 70.8% in those cases who benefited from a R0-resection (24/30 patients: R0-resection rate 80.0%).ConclusionsIn this study the 3-year survival for locally advanced gastric cancer treated by NACT prior to “D2” surgical resection, compares favourably with historical series treated by surgery alone. Patients who obtained T-downstaging and subsequently benefited from a R0-resection had a definitely better chance of cure, according to a complete 3-year follow-up.
Journal: European Journal of Surgical Oncology (EJSO) - Volume 32, Issue 10, December 2006, Pages 1105–1109