کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3988021 1601457 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The differential response to chemotherapy of ovarian metastases from colorectal carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
The differential response to chemotherapy of ovarian metastases from colorectal carcinoma
چکیده انگلیسی

Patients and methodsAll patients with metastatic (ovarian and extraovarian) CRC who underwent resection of ovarian metastases in our institution from April 1988 to August 2006 were analyzed and the response to preoperative chemotherapy was evaluated according to the RECIST criteria, and analyzed with respect to the sites of metastases (ovarian and extraovarian).ResultsThe studied population consisted of 23 women. At presentation, 20 patients had symptoms. Preoperative chemotherapy resulted in tumor control of measurable extraovarian metastases in 65% of cases. In contrast, no objective tumor response of ovarian metastases was observed, disease stabilization was obtained in only 3 patients (13%), and progression or occurrence of new ovarian metastases were observed in 20 patients (87%) (p = 0.0005).With a median follow-up of 54 months [15–229], median overall survival was 30 months, and 3-year overall survival was 18%.ConclusionOvarian metastases are less responsive to chemotherapy compared to other sites. As these “metastatic sanctuaries” often cause symptoms, surgical resection should always be considered for ovarian metastases, even in the case of associated extraovarian metastases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 34, Issue 12, December 2008, Pages 1335–1339
نویسندگان
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