کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3988049 1601489 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemoocclusion vs chemoperfusion for treatment of advanced hepatocellular carcinoma: A randomised trial
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Chemoocclusion vs chemoperfusion for treatment of advanced hepatocellular carcinoma: A randomised trial
چکیده انگلیسی

AimsTransarterial chemoembolization (TACE) can be associated with considerable toxicity and treatment-associated mortality. Transient transarterial chemoocclusion (TACO) using degradable starch microspheres (DSM) has been proposed as a potentially safer alternative while maintaining anti-tumour efficiency. In a randomised phase II trial TACO was compared to transarterial chemoperfusion without DSM (TACP).MethodsSeventy-four patients with advanced HCC were randomised to two treatment arms: (i) TACO (600–1200 mg DSM) and (ii) TACP. In both arms regional chemotherapy consisted of cisplatin (100 mg/m2) and doxorubicin (60 mg/m2). Both arms were corresponding in terms of age, gender, liver performance state, and tumour-stage. A maximum of six treatment cycles was applied in monthly intervals. Follow-up was performed in terms of tumour response, time to progression, survival and quality of life.ResultsTumour response rates did not differ significantly between the two treatment arms, however, there was a tendency towards higher response rates in the TACO arm (TACO vs TACP): partial response: 26 vs 9%, stable disease: 41 vs 55%, progressive disease: 33 vs 36%. Time to tumour progression (32 vs 27 weeks), and overall survival (60 vs 69 weeks) were not significantly different. Grade 4 adverse events were rare in both arms and treatment-associated mortality was not observed. In addition, there was no significant difference in terms of quality of life under therapy (EORTC).ConclusionTACO with DSM did not improve response or survival significantly compared to TACP in advanced non-resectable HCC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 32, Issue 2, March 2006, Pages 201–207
نویسندگان
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