کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3988148 1601482 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Debulking surgery for advanced thymoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Debulking surgery for advanced thymoma
چکیده انگلیسی

AimsThis study was conducted to evaluate the efficacy of debulking surgery in the treatment of locally advanced but operable malignant thymoma.MethodsWe reviewed 43 cases with incompletely resected stage III and IVa malignant thymoma managed between January 1987 and December 2002.ResultsTwenty-two had stage III and 21 had stage IVa disease. Maximal debulking was performed in 15 patients, nine with stage III and six with stage IVa disease. Nine patients also had myasthenia gravis (MG). Using univariate Kaplan–Meier analysis, we found that maximal debulking surgery, RT, and with the presence of MG were associated with better survival. Debulking resulted in a better outcome than non-debulking surgery (mean survival: 106 months vs 57.2 months). After adjustment with multivariate analysis, RT and MG were both associated with better survival. CT did not appear to be beneficial for advanced thymoma.ConclusionsRT is independently associated with a better outcome in locally advanced thymoma. Debulking surgery apparently allows for a better response to RT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 32, Issue 9, November 2006, Pages 1000–1005
نویسندگان
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