کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3988302 1601487 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A simple measure of reliability in clinical trials of surgical adjuvant radiotherapy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
A simple measure of reliability in clinical trials of surgical adjuvant radiotherapy
چکیده انگلیسی

AimsThe ‘number needed to treat’ (NNT) is a measure of therapeutic effect and is defined as the number of patients needed to be treated, so that the treatment of one of them is successful. Since many patients or physicians find this way to describe therapeutic potency very intuitive, I calculated the NNTs for the surgical adjuvant radiotherapy of different malignant neoplasias.MethodsThis computation was applied to selected, prospective, randomized trials or meta-analyses on adjuvant or adjunctive radiotherapy of epithelial or glial malignancies.ResultsAmong 17 NNTs calculated for trials reporting improvements in local relapse rates 2 are smaller than 5, 8 are in the range from 5 to 10 and 7 are larger than 10 (median follow-up 5 years; range 3–20). In contrast, only 2 NNTs from 10 trials reporting survival advantages are smaller than 10 (median follow-up 4 years; range 1–20).ConclusionsNNTs correctly reflect that adjuvant radiotherapy has a far more pronounced impact on the probability of local recurrence of a malignancy as opposed to patient's survival.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 32, Issue 4, May 2006, Pages 395–399
نویسندگان
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