Malignant Pleural Mesothelioma with Extensive Skeletal Muscle Metastasis

We treated a 61-year-old man with malignant pleural mesothelioma complicated by extensive skeletal muscle metastases. The initial presentation included rapidly progressive weakness and stiffness in four extremities. The magnetic resonance image (MRI) and the computed tomography (CT) scan revealed disseminated symmetrical intramuscular nodular lesions. Excisional biopsy was taken and pathology confirmed the presence of a biphasic metastatic mesothelioma by immunohistochemical (IHC) staining. The patient survived for only 3 months from the onset of the symptoms despite of the administration of emergency chemotherapy and optimal supportive care.