Procedure Triggers Rapid Progression of Renal Cell Carcinoma

We present two renal cell carcinoma (RCC) cases with rapid disease progression within one month of an interventional procedure. Analysis of the clinical courses and laboratory data suggested that a burst of inflammatory cytokines following the procedures could have been the main reason for cancer progression. Higher tumor burden and the presence of paraneoplastic syndrome could be indicators predicting such a complication. Although the mechanism is not well understood, identifying such patients is important.