کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3989415 1258678 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Frequent BRAF or EGFR Mutations in Ciliated Muconodular Papillary Tumors of the Lung
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Frequent BRAF or EGFR Mutations in Ciliated Muconodular Papillary Tumors of the Lung
چکیده انگلیسی

IntroductionCiliated muconodular papillary tumors (CMPTs) are recently characterized, rare peripheral nodules of the lung. These small tumors are histologically comprised of a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, and consistently follow a benign clinical course. However, the histogenesis of CMPTs remains uncertain.MethodsWe performed detailed genomic analyses of 10 archived CMPT cases, using next-generation sequencing and high-resolution melting analysis.ResultsMutations were identified in eight of the 10 cases (80%); four cases harbored the BRAF-V600E mutation, one case harbored the BRAF-G606R mutation, and three cases harbored deletions in exon 19 of EGFR. All of the deletions in EGFR were of the E746-T751/S752V subtype.ConclusionsThe high prevalence of driver gene mutations in CMPTs supports the notion that these lesions are neoplastic rather than reactive or metaplastic.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Thoracic Oncology - Volume 11, Issue 2, February 2016, Pages 261–265
نویسندگان
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