کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3989651 1258690 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adrenal Metastases in Lung Cancer: Clinical Implications of a Mathematical Model
ترجمه فارسی عنوان
متاستاز آدنال در سرطان ریه: پیامدهای بالینی یک مدل ریاضی
کلمات کلیدی
سرطان ریه غیر سلولی کوچک، متاستاز آدنوم، گسترش لنفاوی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

Adrenal gland metastases are common in lung cancer. It is well recognized that aggressive treatment of solitary adrenal metastases leads to improved outcomes but the exact nature of adrenal deposits is not well understood. Controversy exists as to the routing of cancer cells to the adrenal gland with some believing that this transmission is lymphatic, in contrast to the more generally accepted theory of hematogenous spread. Recently published mathematical modeling of cancer progression strongly supports the lymphatic theory. With that in mind, we performed a literature review to look for biological plausibility of simulation results and believe that evidence supports the contention that metastases to the adrenal gland can be routed by means of lymphatic channels. This could explain improved survival for patients in whom solitary adrenal metastases are managed aggressively with surgical or radiation modalities. We are calling for clinical trials prospectively testing this hypothesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Thoracic Oncology - Volume 9, Issue 4, April 2014, Pages 442–446
نویسندگان
, , , , , ,