کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3990376 1258733 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
EGFR Gene Alterations in a Norwegian Cohort of Lung Cancer Patients Selected for Surgery
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
EGFR Gene Alterations in a Norwegian Cohort of Lung Cancer Patients Selected for Surgery
چکیده انگلیسی

IntroductionLung cancer is the leading cause of cancer-related deaths worldwide. New therapies targeting the epidermal growth factor receptor (EGFR) tyrosine kinase are promising and show high response rates in the subset of patients with activating mutations in EGFR. The frequency of these mutations is largely unknown in unselected Caucasian patients.MethodsMutation analysis of EGFR exons 18–21 was performed on 240 lung cancer samples using the TheraScreen EGFR mutation kit and denaturing high-performance liquid chromatography in addition to sequencing.ResultsIn a cohort of 240 Norwegian lung cancer patients selected for surgery, we identified 18 tumors with EGFR-activating mutations (7.5%, 14 women and 4 men), of which 14 were adenocarcinomas, 2 squamous cell carcinomas, and 2 bronchoalveolar carcinomas. Five of the mutations were found in patients with more than 20 pack-years of smoking history.ConclusionThe frequency of EGFR mutations is lower in our cohort than among Asian lung cancer patients and present in both men and women and smokers and never-smokers. However, the frequency is significantly higher among women and never-smokers and among patients with adenocarcinomas.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Thoracic Oncology - Volume 6, Issue 5, May 2011, Pages 947–950
نویسندگان
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