کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3992336 | 1258807 | 2008 | 5 صفحه PDF | دانلود رایگان |
BackgroundCase reports of primary pulmonary artery sarcomas are very rare.MethodsWe described herein eight new cases diagnosed between December 2000 and December 2004.ResultsThere were four men and four women, with median age of 52 years. Presenting symptoms mimicked pulmonary emboli in all cases. There were six “intimal sarcomas” and two leiomyosarcomas. In six cases, we observed initial metastasis in lung (six cases), in bone (two cases), and in brain (two cases), and adrenal gland (one case). The palliative treatments included surgical desobstruction (six cases), conformational radiotherapy (four cases), and chemotherapy (seven cases). Doxorubicin-based regimen failed in seven cases. All patients died (median survival: 8 months, extremes 5–20 months).ConclusionThose eight cases illustrate the high incidence of initial metastasis and the very poor outcome of primary pulmonary artery sarcomas despite classic doxorubicin-based chemotherapy.
Journal: Journal of Thoracic Oncology - Volume 3, Issue 8, August 2008, Pages 907–911