کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3994486 | 1258894 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Treatment-related peripheral neuropathy in multiple myeloma: the challenge continues Treatment-related peripheral neuropathy in multiple myeloma: the challenge continues](/preview/png/3994486.png)
SummaryIntroduction of the proteasome inhibitor bortezomib and the immunomodulatory drugs thalidomide and lenalidomide has substantially improved outcomes for patients with multiple myeloma. As a result, these drugs have become cornerstones of current antimyeloma treatment regimens. However, after several years of clinical experience it has become apparent that peripheral neuropathy is the most common and potentially disabling non-haematological side-effect associated with thalidomide and bortezomib. Maximising treatment benefit while preserving quality of life therefore requires a careful balance between achieving optimum activity and minimising toxicity, including neuropathy, to further enhance efficacy. In this review, we discuss all aspects of drug-induced peripheral neuropathy in myeloma, with a particular focus on thalidomide and bortezomib.
Journal: - Volume 11, Issue 11, November 2010, Pages 1086–1095