کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3995997 | 1258966 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma](/preview/png/3995997.png)
چکیده انگلیسی
SummaryGenetic alterations that lead to loss or changes in tumour-suppressor genes are known to contribute to oral carcinogenesis. Traditional molecular methods to detect such losses have relied on mutation analysis or deletion of the gene. However, epigenetic mechanisms could also contribute to silencing of tumour-suppressor genes. Methylation regions rich in CpG promoters prevent DNA transcription by changing the binding of histone complexes. The substantial contribution of methylation, specifically in oral squamous-cell carcinoma, is now being realised and investigated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 7, Issue 1, January 2006, Pages 77–82
Journal: - Volume 7, Issue 1, January 2006, Pages 77–82
نویسندگان
Patrick K Ha, Joseph A Califano,