Sunshine and Rash: Testing the Role of Sunscreen to Prevent Epidermal Growth Factor Receptor Inhibitor–Induced Rash

Most patients who receive epidermal growth factor receptor (EGFR) inhibitors develop a rash. To date, no effective palliative therapy has been developed for these rashes. This review describes the rationale behind N05C4, a placebo-controlled trial of sunscreen as an intervention to prevent EGFR inhibitor–related rash.