کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3997841 1259178 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High-intensity focused ultrasound: Noninvasive treatment for local unresectable recurrence of osteosarcoma
ترجمه فارسی عنوان
سونوگرافی متمرکز شده با شدت بالا: درمان غیرتهاجمی برای عود عصب موضعی استئوسارکومی ناخواسته
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی


• HIFU is a valuable option for the treatment of local unresectable recurrence of osteosarcoma, with good local control.
• HIFU is a safe treatment for local unresectable recurrence of osteosarcoma, without severe complications.
• We believe our data from HIFU treatment will attract attentions from oncologists and orthopedist.

ObjectiveLocal unresectable recurrence of osteosarcoma is one of the most challenging tumors to treat. High-intensity focused ultrasound (HIFU) is a new, noninvasive technique with potential to ablate and inactivate tumors. Treatment of solid tumors with HIFU has been reported. In this study, we assessed safety and efficacy of HIFU in treating local unresectable recurrence of osteosarcoma.MethodsWe performed a retrospective analysis of 27 patients who had local unresectable recurrence of osteosarcoma from 2006 to 2010. Changes of biochemical markers and pain rating, response rate, disease control rate, local disease progression-free survival, progression-free survival (PFS) and overall survival (OS) were used to evaluate efficacy of HIFU treatment.ResultsHIFU resulted in a significant change in alkaline phosphatase and lactic acid dehydrogenase and a remarkably relief in pain rating, without severe side effects. According to MRI examination 4–6 weeks after HIFU treatment, 2 (7.4%) patients had complete response (CR), 12 (44.4%) had partial response (PR), 9 (33.3%) had stable disease (SD) and 4 (14.8%) had progression disease (PD). The response rate was 51.8% and the local disease control rate was 85.2%. The 1-, 2-, and 3-year local disease control rates were 59.2%, 40.7% and 33.1%, respectively. The median local disease progression-free time was 14 months, the median progression-free time was 13 months and the median over-all survival time was 21 months. Patients without pulmonary metastasis had a better local disease control rate at 1-,2-,3-year and a longer local disease progression-free time, progression-free time, over-all survival time than patients with pulmonary metastasis.ConclusionHIFU is a safe and noninvasive treatment for local unresectable recurrence of osteosarcoma, with good local control and without severe complications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgical Oncology - Volume 24, Issue 1, March 2015, Pages 9–15
نویسندگان
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