کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3999064 | 1601774 | 2009 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Family Cancer Syndromes: Inherited Deficiencies in Systems for the Maintenance of Genomic Integrity
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Familial cancer syndromes have revealed important fundamental features regarding how all cancers arise through destabilization of the genome, such that somatic evolution can select for the disruption of critical cellular coordinating and regulatory features. The authors examine those cellular genes and systems whose normal role is to preserve genomic integrity and relate them to the genetic foundations of heritable cancers. By examining how these cellular systems normally function, how family cancer genes are able to affect the process of tumor progression can be learned. In so doing, a clearer picture of how sporadic cancers arise is additionally gained.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgical Oncology Clinics of North America - Volume 18, Issue 1, January 2009, Pages 1–17
Journal: Surgical Oncology Clinics of North America - Volume 18, Issue 1, January 2009, Pages 1–17
نویسندگان
Huferesh Darbary, Daniel L. Stoler, Garth R. Anderson,