Management and Extent of Resection for Intrahepatic Cholangiocarcinoma

Intrahepatic cholangiocarcinoma is the second most common primary liver cancer behind hepatocellular cancer. Although it is an uncommon malignancy, several reports have documented a significant rise in incidence, not only in the United States, but worldwide over the last several decades. As a result, interest in understanding the presentation, diagnosis, natural history, and efficacy of various treatment modalities has increased. This article reviews the clinical presentation, preoperative work-up, surgical management, and outcomes of patients undergoing resection for intrahepatic cholangiocarcinoma. Treatment options in unresectable patients are also reviewed.