Heterogeneity in D׳Amico classification-based low-risk prostate cancer: Differences in upgrading and upstaging according to active surveillance eligibility

D׳Amico low-risk patients did not have a homogeneous histology at RP. Especially, non-AS candidates were at a higher risk of either upgrading or upstaging at final pathology. Tumor involvement greater than 50% per core was the most powerful indicator of adverse pathology. Therefore, DʼAmico low-risk criteria are not safe enough to identify AS candidates.