کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4000001 1259363 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Percentage of cancer involvement in positive cores can predict unfavorable disease in men with low-risk prostate cancer but eligible for the prostate cancer international: Active surveillance criteria
ترجمه فارسی عنوان
درصد دخالت سرطان در هسته های مثبت می تواند بیماری نامطلوب را در مردان مبتلا به سرطان پروستات کم خطر پیش بینی کند اما واجد شرایط برای سرطان پروستات بین المللی است: معیارهای مراقبت های فعال
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

ObjectivesTo identify predictive factors of unfavorable disease and of biochemical failure in patients treated with radical prostatectomy but eligible for active surveillance (AS) according to Prostate Cancer Research International: Active Surveillance (PRIAS) criteria. We aimed to introduce and validate the percentage of cancer involvement in positive cores (CIPC) as potential worse predictive factor.MethodsFrom January 2002 to December 2007, 750 consecutive subjects underwent radical prostatectomy at a single institution. We identified 147 (19.05%) patients who were eligible for AS based on PRIAS criteria: clinical stage T1c or T2 disease, prostate-specific antigen level of≤10 ng/ml, Gleason score≤6, prostate-specific antigen-D of<0.2 ng/ml2, and fewer than 3 positive biopsy cores. CIPC was included in the analysis.ResultsOf the 147 patients, 95 (66.43%) patients had favorable disease, whereas 48 (33.57%) had unfavorable disease. In multivariate logistic regression, maximum cancer length (odds ratio 12.52, P<0.01) and CIPC (odds ratio 1.70, P<0.01) represented independent predictors of unfavorable prostate cancer. The area under the receiver operating characteristics curve analysis revealed significantly higher performance after including CIPC to the PRIAS criteria (0.61 vs. 0.94, P<0.01). A cutoff of 0.4 mm of CIPC was set to predict unfavorable disease with 93% specificity, 76% sensibility, and 87% accuracy based on the receiver operating characteristics curve analysis. Finally, the 3- and 5-years biochemical recurrence (BCR)-free survival were significantly lower in subjects with CIPC≥0.4 mm, 88.4 % and 81.0% vs. 97.8% and 95.7%, respectively (P< 0.01).ConclusionsOur findings suggest that the inclusion of CIPC to the prostate biopsy features could be helpful to avoid misclassification in patients eligible for AS according to the PRIAS criteria.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Urologic Oncology: Seminars and Original Investigations - Volume 32, Issue 3, April 2014, Pages 291–296
نویسندگان
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