The risk of biopsy-detectable prostate cancer using the prostate cancer prevention Trial Risk Calculator in a community setting

Materials and methodsRisks of prostate cancer (CaP) and high-grade CaP were evaluated using the Prostate Cancer Prevention Trial Risk Calculator (PCPTRC) in an age-stratified random sample of 1,021 Caucasian and African-American men with no previous diagnosis of CaP, aged 55–74 years, residing in King County, WA, USA.ResultsMedian PCPTRC risks of CaP (high-grade CaP) were 15.6% (1.2%), 18.7% (2.0%), 18.5% (2.2%), and 26.4% (5.1%) for 55–59, 60–64, 65–69, and 70–74-year-old men, respectively; 25.2% of men aged 55–59 had a 25% or greater PCPTRC risk of CaP; this increased to 53.1% in men aged 70–74; 9.4% of men aged 55–59 had a 6% or greater PCPTRC risk of high-grade CaP, increasing to 44.1% in men aged 70–74.ConclusionsPCPTRC risk of CaP in a community of US males is high and confounded with overdetected cancers. In contrast, average community PCPTRC risk of high-grade disease is low and increases gradually by age and may better serve for counseling purposes.