Phospholipase-C gamma-1 (PLCγ-1) is critical in hepatocyte growth factor induced in vitro invasion and migration without affecting the growth of prostate cancer cells

Targeting PLCγ-1 by way of a hammerhead ribozyme to PLCγ-1 is an effective method in reducing invasive phenotype of prostate cancer. PLCγ-1 is a signalling intermediate that has prime influence on HGF induced cellular invasion and migration without affecting the growth of the cells.